Donna Mae Yeo was born in Winnipeg, Manitoba where she lived until her father was posted to Ottawa. She attended Lisgar Collegiate in Ottawa. After the war, they returned to Winnipeg, where she attended Kelvin High School. She studied at the University of Manitoba, graduating with a Bachelor of Interior Design in 1950. Yeo loved connecting with people, and at university she joined Alpha Delta Pi Sorority. She was a founding member of the Student Society of Interior Designers, later the Professional Interior Designers Institute of Manitoba, in 1949.
In 1950, Yeo moved to Vancouver and worked as a designer for Ridgewood Studios, serving on the Executive Board of the Interior Designers Institute of British Columbia. In 1952, she returned to Winnipeg to work for Wilson Stationary Co, establishing its Office Planning Division.
Yeo freelanced as an Interior Designer for various commercial clients until 1979. An Emeritus Member of PIDIM and dedicated to the Interior Design profession, she was a Charter Member of both the Interior Designers Institute of Manitoba and Interior Designers of Canada; President of IDIM; Director, Public Relations Coordinator and Advisor for five Interior Design trade exhibitions; initiated PIDIM's role in the Ronald McDonald House project and participated in the 2001 Kapyong Barracks Design Charrette.
In her desire to improve her community, Yeo served as President of the Councils of Women of Winnipeg and served in several positions for the Provincial Council of Women of Manitoba. She was a charter member and President of the Altrusa Club of Winnipeg, a women's service club. With Altrusa she founded and operated TOTS (Take-Out-Toy Service), a toy-lending service for children with special needs, and helped found the Language Bank of Winnipeg, a 24-hour emergency translation service. She served as President of Schoolmasters Wives, Regional Alumnae Director and Permanent Alumnae Secretary for Alpha Delta Pi Sorority. She was a force on the Assiniboine Park-Fort Garry Residents Advisory Group, was appointed by Winnipeg City Council to the Civic Charities Endorsement Bureau, which she chaired. She was one of the founding members of W.I.N. (Winnipeg into the Nineties), a non-partisan citizens group to provide informed leadership and set new direction for municipal policy. She was a member of Westworth United Church and upon moving to Vernon in 2009, a member of the UCW Jubilee unit of Trinity United Church.